<div class="page photo" style="">
<article>
<header style="
background-image:url(/imageLibrary/droplets.jpg);
">
<div class="box">
<div class="intro" style="color: #000;">
<h1 style="color: #000 !important;">Abstract 20150317</h1>
<p class="summary"></p>
</div>
</div>
</header>
<div class="main">
<div class="container">
<p class="byline"> </p>
<p><strong><의공학연구소 정례세미나></strong></p><p><strong>연자 : 김형민박사 (KIST)</strong></p><p><strong>일시 : 3월 17일 화요일 17:00~</strong></p><p><strong>장소 : 아산생명과학연구원 교육연구관 4층 회의실 </strong></p><p><strong>Image-guided navigation for non-invasive neuromodulation using low-intensity focused </strong><strong>ultrasound</strong></p><p><strong><introduction></introduction></strong></p><p>Focused ultrasound (FUS) is an emerging non-invasive neuromodulation modality, which has a superior spatial specificity and penetration depth over the conventional non-invasive neuromodulation techniques, such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS). Recently, low-intensity pulsed FUS was shown to either excite or suppress the region-specific brain functions in animals (rodents and rabbits). In order to translate the neuromodulatory evidences of FUS to large animals and humans, we were motivated to develop an image-guided navigation system, which can provide overlaid focal location of single-element FUS transducer in real-time onto the pre-acquired multi-modal neuroimaging data.</p><p><strong><materials methods="" and=""></materials></strong></p><p>The software was implemented in C , based on an open source library (IGSTK: Image-Guided Surgery Toolkit) and a cross-platform application and graphical user interface (GUI) framework (QT). Multi-modal neuroimaging data in DICOM format, e.g. computed tomography (CT), magnetic resonance imaging (MRI), functional MRI (fMRI), and diffusion tensor imaging (DTI), can be imported. The operator can define entry and target points of the desired sonication paths, based on the anatomical and functional neuroimaging data. The real-time spatial information of FUS transducers, reference tracker, and pointer are tracked by optical tracking camera (Vicra, Northern Digital Inc., ON, Canada). The real-time overlay of the sonication focus on pre-acquired medical imaging modalities can be provided, whereby the focal location of the FUS transducer was pre-calibrated in term of optical tracking system. The quantitative information related to the desired sonication path (e.g. distance to target location) can be monitored while positioning the FUS transducer onto the specific area of the human brain.</p><p><strong><conclusion></conclusion></strong></p><p>According to the recent studies, the safe application of transcranial FUS to human brains seems promising by using low acoustic intensity and an appropriate pulsing scheme. The developed system will be useful in increasing accuracy in transcranial FUS to humans, which can be potentially used for various neurotherapeutic applications.</p><p><img src="/uploads/552cd02c9d4bd.PNG"></p><p><img src="/uploads/552cd0363b623.PNG"></p>
</div>
</div>
</article>
</div><!-- /page-->