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<h1 style="color: #000 !important;">Abstract 20150922</h1>
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<p><strong style="background-color: initial;"><의공학연구소 특별세미나></strong></p><p><strong>연자 : 고인갑 교수 (웨이크포레스트 재생의학연구소)</strong></p><p><strong>주제 : Bioengineering Whole Kidney Construct for Renal Transplantation</strong></p><p><strong>일시 : 9월 22일 화요일 17:00~</strong></p><p><strong>장소 : 서울아산병원 동관 6층 5세미나실</strong></p><p><strong><br></strong></p><p><strong><abstract></abstract></strong></p><p><strong><br></strong></p><p><strong>Bioengineering
Whole Kidney Construct for Renal Transplantation</strong></p><p><strong></strong></p><p>In Kap
Ko, Joao Paulo Zambon, Mehran Abolbashari, Tae Hyoung Kim, Jennifer Huling, </p><p>Ick-Hee Kim, Anthony Atala, James J. Yoo</p><p>Wake Forest Institute
for Regenerative Medicine, Wake Forest University School of Medicine,</p><p>Medical Center
Boulevard, Winston-Salem, NC 27157, USA</p><p>Kidney transplantation is
the only definitive treatment for end stage renal disease (ESRD). However, the
availability of transplantable kidneys is limited. Recent advances in the field
of bioengineering whole kidney constructs have provided a promising solution to
address the shortage. Previously, we have developed decellularization and
recellularization methods that allowed efficient recellularizaiton including
re-endothelia-lization of vasculatures and repopulation with renal cells using acellular
porcine kidney scaffolds, followed by promising outcomes from short-term
implantation <strong>[1]</strong>. To make this
technology amenable for clinical translation, this study aimed to evaluate vascular patency of bioengineered porcine
kidney constructs seeded with autologous cell sources in a pig implantation model.
The success of work will lead to the development of an alternative
treatment method for patients with ESRD, and address the critical shortage of
transplantable donor kidneys. </p><p><strong>References</strong></p><p>[1]
Ko IK et al, Enhanced
re-endothelialization of acellular kidney scaffolds for whole organ engineering
via antibody conjugation of vasculatures, Technology 2(3): 243-253 (2014). </p>
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